Journal of Medicinal Chemistry

Journal of Medicinal Chemistry
Volume 42, Issue 8 (April 22, 1999)
Copyright © 1999 American Chemical Society

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1329-1329	[Full Article - PDF]
ANNOUNCEMENTS
1329-1329	[Full Article - PDF]
COMMUNICATIONS TO THE EDITOR
1330-1332	Synthesis and Antitumor Activity of Novel Thioester Derivatives of Leinamycin Yutaka Kanda, Tadashi Ashizawa, Shingo Kakita, Yuichi Takahashi, Motomichi Kono, Mayumi Yoshida, Yutaka Saitoh, and Masami Okabe [Full Article - PDF]
EXPEDITED ARTICLES
1333-1340	Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I Anil Vasudevan, Yimin Qian, Andreas Vogt, Michelle A. Blaskovich, Junko Ohkanda, Said M. Sebti, and Andrew D. Hamilton [Full Article - PDF]
ARTICLES
1341-1347	Comparison of Four ⁶⁴Cu-Labeled Somatostatin Analogues in Vitro and in a Tumor-Bearing Rat Model: Evaluation of New Derivatives for Positron Emission Tomography Imaging and Targeted Radiotherapy Jason S. Lewis, Michael R. Lewis, Ananth Srinivasan, Michelle A. Schmidt, Jian Wang, and Carolyn J. Anderson [Full Article - PDF]
1348-1357	Identification of Highly Selective Inhibitors of Collagenase-1 from Combinatorial Libraries of Diketopiperazines Anna Katrin Szardenings, Valery Antonenko, David A. Campbell, Nuria DeFrancisco, Satoru Ida, Lihong Shi, Nikolai Sharkov, David Tien, Yongwen Wang, and Marc Navre [Full Article - PDF]
1358-1366	Conformational and Quantitative Structure-Activity Relationship Study of Cytotoxic 2-Arylidenebenzocycloalkanones Jonathan R. Dimmock, N. Murthi Kandepu, Adil J. Nazarali, Travis P. Kowalchuk, Narasimhan Motaganahalli, J. Wilson Quail, Patricia A. Mykytiuk, Gerald F. Audette, Lata Prasad, Pál Perjési, Theresa M. Allen, Cheryl L. Santos, Jen Szydlowski, Erik De Clercq, and Jan Balzarini [Full Article - PDF]
1367-1375	Secondary Structure Peptide Mimetics: Design, Synthesis, and Evaluation of -Strand Mimetic Thrombin Inhibitors P. Douglas Boatman, Cyprian O. Ogbu, Masakatsu Eguchi, Hwa-Ok Kim, Hiroshi Nakanishi, Bolong Cao, J. Paul Shea, and Michael Kahn [Full Article - PDF]
1376-1383	Bound Structures of Novel P3-P1' -Strand Mimetic Inhibitors of Thrombin Robert St. Charles, John H. Matthews, Erli Zhang, and A. Tulinsky [Full Article - PDF]
1384-1392	5'-N-Substituted Carboxamidoadenosines as Agonists for Adenosine Receptors Maarten de Zwart, Angeliki Kourounakis, Huub Kooijman, Anthony L. Spek, Regina Link, Jacobien K. von Frijtag Drabbe Künzel, and Ad P. IJzerman [Full Article - PDF]
1393-1400	N⁶,5'-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A₃ Receptor Erica W. van Tilburg, Jacobien von Frijtag Drabbe Künzel, Miriam de Groote, Roel C. Vollinga, Anna Lorenzen, and Ad P. IJzerman [Full Article - PDF]
1401-1414	Chicoric Acid Analogues as HIV-1 Integrase Inhibitors Zhaiwei Lin, Nouri Neamati, He Zhao, Yoshimitsu Kiryu, Jim A. Turpin, Claudia Aberham, Klaus Strebel, Kurt Kohn, Myriam Witvrouw, Christophe Pannecouque, Zeger Debyser, Erik De Clercq, William G. Rice, Yves Pommier, and Terrence R. Burke, Jr. [Full Article - PDF]
1415-1421	1-(N-Alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple Synthetic Polyamine Analogues That Differentially Alter Tubulin Polymerization Heather K. Webb, Zhiqian Wu, Nilantha Sirisoma, Hyo Chol Ha, Robert A. Casero, Jr., and Patrick M. Woster [Full Article - PDF]
1422-1427	Synthesis and Voltage-Clamp Studies of Methyl 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate Racemates and Enantiomers and of Their Benzofuroxanyl Analogues Sonja Visentin, Pascale Amiel, Roberta Fruttero, Donatella Boschi, Christian Roussel, Laura Giusta, Emilio Carbone, and Alberto Gasco [Full Article - PDF]
1428-1440	Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II Tasir S. Haque, A. Geoffrey Skillman, Christina E. Lee, Hiromu Habashita, Ilya Y. Gluzman, Todd J. A. Ewing, Daniel E. Goldberg, Irwin D. Kuntz, and Jonathan A. Ellman [Full Article - PDF]
1441-1447	Synthesis and Dopamine Receptor Modulating Activity of Novel Peptidomimetics of L-Prolyl-L-leucyl-glycinamide Featuring ,-Disubstituted Amino Acids Margaret C. Evans, Ashish Pradhan, Shankar Venkatraman, William H. Ojala, William B. Gleason, Ram K. Mishra, and Rodney L. Johnson [Full Article - PDF]
1448-1458	Novel Cyclopropapyrroloindole Derivative (AT-3510) Bearing Methoxycarbonyl and Trifluoromethyl Groups Yasumichi Fukuda, Hirosuke Furuta, Yoshie Kusama, Hiroyuki Ebisu, Yasuo Oomori, and Shiro Terashima [Full Article - PDF]
1459-1465	*Antineoplastic Agents. 410. Asymmetric Hydroxylation of trans-Combretastatin A-4* George R. Pettit, Brian E. Toki, Delbert L. Herald, Michael R. Boyd, Ernest Hamel, Robin K. Pettit, and J. Charles Chapuis [Full Article - PDF]
1466-1472	5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification Lin Zhi, Christopher M. Tegley, Keith B. Marschke, Dale E. Mais, and Todd K. Jones [Full Article - PDF]
BRIEF ARTICLES
1473-1476	Bisphosphonate Prodrugs: Synthesis and in Vitro Evaluation of Novel Clodronic Acid Dianhydrides as Bioreversible Prodrugs of Clodronate Marko Ahlmark, Jouko Vepsäläinen, Hannu Taipale, Riku Niemi, and Tomi Järvinen [Full Article - PDF]
1477-1480	Synthesis and Antimalarial Activity of 11 Dispiro-1,2,4,5-tetraoxane Analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes Substituted at the 1 and 10 Positions with Unsaturated and Polar Functional Groups Yuxiang Dong, Hugues Matile, Jacques Chollet, Ronald Kaminsky, James K. Wood, and Jonathan L. Vennerstrom [Full Article - PDF]